Gene Therapy MCQs with Answers

adminJune 13, 2024Last Updated: October 14, 2024

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Welcome to the Gene Therapy MCQs with Answers. In this post, we have shared Gene Therapy Online Test for different competitive exams. Find practice Gene Therapy Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Gene Therapy.

Gene therapy represents a new kind of medical treatment that might one day treat, even prevent, specific genetic disorders by inserting, deleting, or altering the genetic material inside a patient’s cells. That is why it promises cure rather than mere management of symptoms.

The principle of the gene therapy is to transfer a normal healthy copy of the gene or correct the defective genes to regain normal functions.

These have ranged from the delivery of therapeutic genes using viral vectors targeting cells to the use of CRISPR-Cas9 as a highly accurate gene editing tool. This promise does make gene therapy capable of either replacing faulty genes or correcting mutations that treat both diverse diseases including inherited disorders such as cystic fibrosis and hemophilia and those complex diseases like cancer.

These have been quite promising clinical trials and research in gene therapy. Indeed, several therapies have reached the stage whereby they are now approved for clinical use. A case in point is Luxturna, a gene therapy developed to treat inherited retinal dystrophy. Comparably, Zolgensma provides unprecedented treatment for spinal muscular atrophy. However, gene therapy has its limitation: ethical concerns, very high costs, and unknown long-term effects; therefore, active research and development to solve some of these issues, improve delivery methods, and be sure that the gene therapy is safe and effective.

Today, it remains one of the most advanced levels of personalized medicine and has a prospect for people with previously untreated genetic diseases, thereby opening further innovation in the realm of medical treatment.

Gene Therapy Online Quiz

By presenting 3 options to choose from, Gene Therapy Quiz which cover a wide range of topics and levels of difficulty, making them adaptable to various learning objectives and preferences. You will have to read all the given answers of Gene Therapy Questions and Answers and click over the correct answer.

Test Name: Gene Therapy MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Gene Therapy

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1 / 40

What is the term for gene therapy aimed at modifying germ cells (sperm or egg cells)?

Somatic gene therapy

In vivo gene therapy

Germline gene therapy

2 / 40

Which delivery method involves directly injecting the therapeutic vector into the affected tissue?

In vivo gene therapy

In situ gene therapy

Ex vivo gene therapy

3 / 40

Which term describes the process of introducing genes into stem cells to treat genetic disorders?

Stem cell transformation

Stem cell transduction

Stem cell transfection

4 / 40

What is the term for gene therapy aimed at modifying somatic cells?

Ex vivo gene therapy

Germline gene therapy

Somatic gene therapy

5 / 40

Which of these is a potential ethical concern in gene therapy?

Physical therapy

Germline modification

Blood transfusion

6 / 40

What is the term for gene therapy that targets cancer cells specifically?

Suicide gene therapy

CAR-T therapy

Oncogene therapy

7 / 40

Which of the following is a non-viral vector used in gene therapy?

Adenovirus

Lentivirus

Liposome

8 / 40

Which term describes the technique of introducing DNA into cells using electric shock?

Photoporation

Sonoporation

Electroporation

9 / 40

In gene therapy, what does the acronym "CRISPR" stand for?

Gene editing

Clustered regularly interspaced short palindromic repeats

Cellular reprogramming

10 / 40

What is the primary reason for using CRISPR/Cas9 in gene therapy?

Precise gene editing

Immune system activation

Gene expression regulation

11 / 40

Which of the following is a potential advantage of using non-viral vectors in gene therapy?

Ability to infect dividing cells

Higher cargo capacity

Reduced immunogenicity

12 / 40

Which gene therapy approach involves inserting a new gene into a random location in the genome?

Ex vivo gene therapy

Insertional mutagenesis

In situ gene therapy

13 / 40

Which enzyme is commonly used in CRISPR gene editing to cut DNA at specific sequences?

Reverse transcriptase

Cas9

DNA polymerase

14 / 40

Which type of gene therapy involves correcting mutations in the DNA of mitochondria?

Plasmid gene therapy

Nuclear gene therapy

Mitochondrial gene therapy

15 / 40

Which of these is a potential side effect of gene therapy using viral vectors?

Decreased gene expression

Immune response

Enhanced metabolic activity

16 / 40

Which term describes a stable integration of introduced genes into the host cell's genome?

Transposon

Transgene

Transcription factor

17 / 40

What is the term for a vector that can replicate independently of the host cell's genome?

Shuttle vector

Insertional vector

Episome

18 / 40

Which term describes the delivery of genetic material using ultrasound?

Electroporation

Sonoporation

Photoporation

19 / 40

What is the term for the process of introducing new genetic material into cells to correct a genetic defect?

Transfection

Transduction

Transformation

20 / 40

What is the primary challenge of using viral vectors in gene therapy?

Difficulty in replication

Limited cargo capacity

Immunogenicity

21 / 40

What is the most common route of administration for gene therapies targeting the liver?

Intravenous injection

Subcutaneous injection

Intramuscular injection

22 / 40

Which regulatory agency oversees the approval of gene therapy products in the United States?

MHRA (Medicines and Healthcare products Regulatory Agency)

EMA (European Medicines Agency)

FDA

23 / 40

Which of these is a potential challenge in delivering gene therapy to the brain?

Rapid cellular turnover

Limited receptor expression

Blood-brain barrier

24 / 40

Which regulatory challenge is specific to gene therapy compared to traditional drugs?

Manufacturing scalability

Long-term safety monitoring

Short-term efficacy

25 / 40

In which phase of clinical trials is gene therapy typically tested for safety and efficacy?

Phase I

Phase III

Phase II

26 / 40

What is the term for a segment of DNA that is capable of moving and replicating within the genome?

Promoter

Transposon

Enhancer

27 / 40

Which vector is commonly used in gene therapy to deliver genes into target cells?

Liposomal vectors

Viral vectors

Plasmid vectors

28 / 40

Which of the following is an example of a monogenic disorder that could be treated with gene therapy?

Type 2 diabetes

Cystic fibrosis

Hypertension

29 / 40

Which type of gene therapy aims to correct genetic mutations in mitochondrial DNA?

Plasmid gene therapy

Mitochondrial gene therapy

Nuclear gene therapy

30 / 40

Which of these is a potential limitation of CRISPR/Cas9 technology in gene therapy?

Off-target effects

Inability to cross cell membranes

Limited gene size

31 / 40

Which type of viral vector is derived from adenovirus and commonly used in gene therapy?

Lentivirus

Retrovirus

Adeno-associated virus (AAV)

32 / 40

What is the term for a gene that can cause cancer when mutated or overexpressed?

Tumor suppressor gene

Proto-oncogene

Oncogene

33 / 40

Which delivery method involves extracting cells, modifying them in vitro, and reinfusing them into the patient?

In vivo gene therapy

Ex vivo gene therapy

In situ gene therapy

34 / 40

What is the main purpose of gene therapy?

Improving organ function

Correcting faulty genes

Enhancing immune response

35 / 40

Which of the following is NOT a potential application of gene therapy?

Curing bacterial infections

Enhancing cognitive function

Treating genetic disorders

36 / 40

Which of these is a potential safety concern in using CRISPR/Cas9 for gene therapy?

Off-target effects

Promoter activity

Vector integration

37 / 40

What is the term for a regulatory sequence that controls the timing and level of gene expression?

Operator

Promoter

Enhancer

38 / 40

Which term describes the transfer of genetic material from one organism to another?

Transduction

Transformation

Transfection

39 / 40

Which type of gene therapy aims to inhibit the expression of a particular gene?

Overexpression therapy

Insertional mutagenesis

Antisense therapy

40 / 40

What is the primary advantage of using lentiviral vectors in gene therapy?

Transduce dividing and non-dividing cells

Low immunogenicity

High cargo capacity

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adminJune 13, 2024Last Updated: October 14, 2024

0 10 2 minutes read