Immunodeficiency Disorders MCQs with Answers

adminApril 3, 2024Last Updated: October 15, 2024

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Welcome to the Immunodeficiency Disorders MCQs with Answers. In this post, we have shared Immunodeficiency Disorders Online Test for different competitive exams. Find practice Immunodeficiency Disorders Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Immunodeficiency Disorders.

These are conditions characterized by inappropriate responses of the body’s immune system to infections and diseases. They are broadly classified according to causation into primary or genetic and secondary or acquired. Most of them are genetic; hence they refer to mutations in genes that affect the functions of cells of the immune system and thus predispose patients to infections. Examples of primary immunodeficiencies include SCID and CVID.

Secondary immunodeficiencies, acquired and due to etiologic factors exogenous to the patient himself, such as infections, malnutrition or immunosuppressive drugs. Probably the most known and frequent secondary immunodeficiency disease is HIV infection that leads to Acquired Immunodeficiency Syndrome (AIDS).

The diagnosis is accompanied by clinical evaluation, immunological testing, and genetic analysis. The patients need early diagnosis coupled with intervention to avoid severe complications in the conditions. Treatment could therefore be administered mainly through immunoglobulin replacement therapy, antibiotics to prevent infections, and sometimes through a stem cell or bone marrow transplant.

The scientific and clinical research of immunodeficiency diseases, such as HIV/AIDS, focuses on understanding the disease mechanism due to genetic or environmental factors that cause immunodeficiency disorders. There have been various advancements in different fields: diagnostic techniques, specific therapies, and the fate of the patient.

Immunodeficiency Disorders Online Quiz

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Test Name: Immunodeficiency Disorders MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Immunodeficiency Disorders

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1 / 40

DiGeorge Syndrome is primarily caused by?

A mutation in the B cell receptor

An HIV infection

A deletion on chromosome 22

2 / 40

Common Variable Immunodeficiency (CVID) usually presents with?

Autoimmune disorders

Recurrent infections

Allergic reactions

3 / 40

Wiskott-Aldrich Syndrome is caused by mutations in which gene?

BTK gene

IL-2 receptor gene

WAS gene

4 / 40

Defects in the IL-2 receptor gamma chain can result in which immunodeficiency?

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

Chronic Granulomatous Disease

5 / 40

What is the genetic inheritance pattern of Wiskott-Aldrich Syndrome?

Autosomal recessive

Autosomal dominant

X-linked recessive

6 / 40

The diagnostic hallmark of Chronic Granulomatous Disease is?

Low immunoglobulin levels

Defective neutrophil function

Lack of thymus

7 / 40

The primary cause of death in patients with Severe Combined Immunodeficiency (SCID) is?

Autoimmune diseases

Infections

Cancer

8 / 40

Selective IgA deficiency mainly affects which immunoglobulin?

IgA

IgG

IgM

9 / 40

Wiskott-Aldrich Syndrome affects which type of cells primarily?

Endothelial cells

Red blood cells

Platelets and immune cells

10 / 40

The absence of the thymus is a hallmark of which syndrome?

DiGeorge Syndrome

Bruton’s Agammaglobulinemia

Common Variable Immunodeficiency

11 / 40

Hyper IgM Syndrome can result from mutations in which of the following?

IgA receptor

Complement factor

CD40 ligand

12 / 40

What is a common treatment for many primary immunodeficiency disorders?

Immunoglobulin replacement therapy

Antibiotics

Antiviral drugs

13 / 40

What is the most common primary immunodeficiency?

Selective IgA deficiency

Common Variable Immunodeficiency

DiGeorge Syndrome

14 / 40

Job's Syndrome is also known as?

Hyper IgM Syndrome

Hyper IgE Syndrome

Hypogammaglobulinemia

15 / 40

A deficiency in which complement component can lead to recurrent Neisseria infections?

C5-C9

C1 esterase

16 / 40

Which immunodeficiency is associated with defects in the phagocyte oxidase enzyme?

Wiskott-Aldrich Syndrome

DiGeorge Syndrome

Chronic Granulomatous Disease

17 / 40

Which primary immunodeficiency involves a defect in neutrophil chemotaxis?

Common Variable Immunodeficiency

Bruton’s Agammaglobulinemia

Leukocyte Adhesion Deficiency

18 / 40

Ataxia-telangiectasia is associated with which kind of defect?

Protein folding

Enzyme production

DNA repair

19 / 40

Which of the following is a primary immunodeficiency disorder?

Severe Combined Immunodeficiency (SCID)

HIV/AIDS

Tuberculosis

20 / 40

In X-linked agammaglobulinemia, the BTK gene mutation affects the development of?

B cells

T cells

Natural killer cells

21 / 40

Which primary immunodeficiency is often treated with bone marrow transplantation?

Hyper IgM Syndrome

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

22 / 40

What is the treatment of choice for Bruton's Agammaglobulinemia?

Corticosteroids

Antifungal medication

Immunoglobulin replacement therapy

23 / 40

Hyper IgM Syndrome involves a defect in which gene?

IL-2 receptor

CD40 ligand

TCR gene

24 / 40

The absence of mature B cells is indicative of which condition?

Chronic Granulomatous Disease

X-linked agammaglobulinemia

Hyper IgM Syndrome

25 / 40

Chronic mucocutaneous candidiasis is primarily due to a defect in which type of cell?

B cells

Phagocytes

T cells

26 / 40

Selective IgA deficiency often results in?

Mucosal infections

Blood clotting disorders

Muscle weakness

27 / 40

The "Boy in the Bubble" disease refers to?

X-linked agammaglobulinemia

Severe Combined Immunodeficiency (SCID)

Common Variable Immunodeficiency

28 / 40

Hyper IgM syndrome is characterized by high levels of which immunoglobulin?

IgM

IgG

IgA

29 / 40

Severe Combined Immunodeficiency (SCID) affects which cells?

Only B cells

Only T cells

Both B and T cells

30 / 40

Ataxia-telangiectasia is associated with increased risk of which disease?

Cancer

Osteoporosis

Cardiovascular disease

31 / 40

Which primary immunodeficiency can present with eczema, thrombocytopenia, and recurrent infections?

Wiskott-Aldrich Syndrome

Hyper IgM Syndrome

DiGeorge Syndrome

32 / 40

Which disorder is characterized by the inability to produce antibodies?

Lymphopenia

Neutropenia

Agammaglobulinemia

33 / 40

A patient with recurrent bacterial infections and low levels of all immunoglobulins might have?

Selective IgA Deficiency

Chronic Granulomatous Disease

Common Variable Immunodeficiency

34 / 40

Which syndrome is associated with defective T-cell development and low calcium levels?

DiGeorge Syndrome

Severe Combined Immunodeficiency (SCID)

Hyper IgM Syndrome

35 / 40

What is the main characteristic of X-linked agammaglobulinemia?

Overproduction of B cells

Lack of B cells

Deficiency of T cells

36 / 40

Which enzyme deficiency leads to Severe Combined Immunodeficiency (SCID)?

Phosphofructokinase

Alpha-1 antitrypsin

Adenosine deaminase

37 / 40

Which disorder is characterized by an inability to clear certain fungal and bacterial infections?

Common Variable Immunodeficiency

DiGeorge Syndrome

Chronic Granulomatous Disease

38 / 40

Wiskott-Aldrich Syndrome includes symptoms like?

Only eczema

Thrombocytopenia, eczema, recurrent infections

Only recurrent infections

39 / 40

Which primary immunodeficiency disorder involves a defect in the CD40 ligand gene?

Selective IgA Deficiency

Common Variable Immunodeficiency

Hyper IgM Syndrome

40 / 40

Chronic Granulomatous Disease is diagnosed using which test?

ELISA

Nitroblue tetrazolium test

Flow cytometry

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adminApril 3, 2024Last Updated: October 15, 2024

0 43 2 minutes read