Immunodeficiency Disorders MCQs with Answers

adminApril 3, 2024Last Updated: October 15, 2024

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Welcome to the Immunodeficiency Disorders MCQs with Answers. In this post, we have shared Immunodeficiency Disorders Online Test for different competitive exams. Find practice Immunodeficiency Disorders Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Immunodeficiency Disorders.

These are conditions characterized by inappropriate responses of the body’s immune system to infections and diseases. They are broadly classified according to causation into primary or genetic and secondary or acquired. Most of them are genetic; hence they refer to mutations in genes that affect the functions of cells of the immune system and thus predispose patients to infections. Examples of primary immunodeficiencies include SCID and CVID.

Secondary immunodeficiencies, acquired and due to etiologic factors exogenous to the patient himself, such as infections, malnutrition or immunosuppressive drugs. Probably the most known and frequent secondary immunodeficiency disease is HIV infection that leads to Acquired Immunodeficiency Syndrome (AIDS).

The diagnosis is accompanied by clinical evaluation, immunological testing, and genetic analysis. The patients need early diagnosis coupled with intervention to avoid severe complications in the conditions. Treatment could therefore be administered mainly through immunoglobulin replacement therapy, antibiotics to prevent infections, and sometimes through a stem cell or bone marrow transplant.

The scientific and clinical research of immunodeficiency diseases, such as HIV/AIDS, focuses on understanding the disease mechanism due to genetic or environmental factors that cause immunodeficiency disorders. There have been various advancements in different fields: diagnostic techniques, specific therapies, and the fate of the patient.

Immunodeficiency Disorders Online Quiz

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Test Name: Immunodeficiency Disorders MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Immunodeficiency Disorders

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1 / 40

Which disorder is characterized by an inability to clear certain fungal and bacterial infections?

Common Variable Immunodeficiency

DiGeorge Syndrome

Chronic Granulomatous Disease

2 / 40

Selective IgA deficiency mainly affects which immunoglobulin?

IgG

IgM

IgA

3 / 40

Wiskott-Aldrich Syndrome affects which type of cells primarily?

Platelets and immune cells

Endothelial cells

Red blood cells

4 / 40

Common Variable Immunodeficiency (CVID) usually presents with?

Recurrent infections

Allergic reactions

Autoimmune disorders

5 / 40

The "Boy in the Bubble" disease refers to?

Common Variable Immunodeficiency

X-linked agammaglobulinemia

Severe Combined Immunodeficiency (SCID)

6 / 40

Wiskott-Aldrich Syndrome includes symptoms like?

Only recurrent infections

Thrombocytopenia, eczema, recurrent infections

Only eczema

7 / 40

What is the genetic inheritance pattern of Wiskott-Aldrich Syndrome?

X-linked recessive

Autosomal recessive

Autosomal dominant

8 / 40

The primary cause of death in patients with Severe Combined Immunodeficiency (SCID) is?

Cancer

Autoimmune diseases

Infections

9 / 40

Which disorder is characterized by the inability to produce antibodies?

Neutropenia

Agammaglobulinemia

Lymphopenia

10 / 40

Wiskott-Aldrich Syndrome is caused by mutations in which gene?

BTK gene

WAS gene

IL-2 receptor gene

11 / 40

Severe Combined Immunodeficiency (SCID) affects which cells?

Only T cells

Only B cells

Both B and T cells

12 / 40

Hyper IgM Syndrome involves a defect in which gene?

IL-2 receptor

CD40 ligand

TCR gene

13 / 40

Hyper IgM Syndrome can result from mutations in which of the following?

Complement factor

IgA receptor

CD40 ligand

14 / 40

Which of the following is a primary immunodeficiency disorder?

Tuberculosis

HIV/AIDS

Severe Combined Immunodeficiency (SCID)

15 / 40

Chronic mucocutaneous candidiasis is primarily due to a defect in which type of cell?

B cells

T cells

Phagocytes

16 / 40

Ataxia-telangiectasia is associated with increased risk of which disease?

Cancer

Osteoporosis

Cardiovascular disease

17 / 40

Which primary immunodeficiency is often treated with bone marrow transplantation?

Hyper IgM Syndrome

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

18 / 40

Which primary immunodeficiency disorder involves a defect in the CD40 ligand gene?

Selective IgA Deficiency

Common Variable Immunodeficiency

Hyper IgM Syndrome

19 / 40

DiGeorge Syndrome is primarily caused by?

An HIV infection

A mutation in the B cell receptor

A deletion on chromosome 22

20 / 40

Defects in the IL-2 receptor gamma chain can result in which immunodeficiency?

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

Chronic Granulomatous Disease

21 / 40

Which primary immunodeficiency involves a defect in neutrophil chemotaxis?

Common Variable Immunodeficiency

Bruton’s Agammaglobulinemia

Leukocyte Adhesion Deficiency

22 / 40

Which enzyme deficiency leads to Severe Combined Immunodeficiency (SCID)?

Adenosine deaminase

Phosphofructokinase

Alpha-1 antitrypsin

23 / 40

A patient with recurrent bacterial infections and low levels of all immunoglobulins might have?

Selective IgA Deficiency

Chronic Granulomatous Disease

Common Variable Immunodeficiency

24 / 40

Which immunodeficiency is associated with defects in the phagocyte oxidase enzyme?

Chronic Granulomatous Disease

DiGeorge Syndrome

Wiskott-Aldrich Syndrome

25 / 40

The absence of the thymus is a hallmark of which syndrome?

DiGeorge Syndrome

Common Variable Immunodeficiency

Bruton’s Agammaglobulinemia

26 / 40

Job's Syndrome is also known as?

Hypogammaglobulinemia

Hyper IgE Syndrome

Hyper IgM Syndrome

27 / 40

Chronic Granulomatous Disease is diagnosed using which test?

ELISA

Flow cytometry

Nitroblue tetrazolium test

28 / 40

Which syndrome is associated with defective T-cell development and low calcium levels?

DiGeorge Syndrome

Severe Combined Immunodeficiency (SCID)

Hyper IgM Syndrome

29 / 40

What is a common treatment for many primary immunodeficiency disorders?

Antibiotics

Immunoglobulin replacement therapy

Antiviral drugs

30 / 40

What is the most common primary immunodeficiency?

Common Variable Immunodeficiency

Selective IgA deficiency

DiGeorge Syndrome

31 / 40

Hyper IgM syndrome is characterized by high levels of which immunoglobulin?

IgG

IgA

IgM

32 / 40

The diagnostic hallmark of Chronic Granulomatous Disease is?

Low immunoglobulin levels

Defective neutrophil function

Lack of thymus

33 / 40

Which primary immunodeficiency can present with eczema, thrombocytopenia, and recurrent infections?

Hyper IgM Syndrome

Wiskott-Aldrich Syndrome

DiGeorge Syndrome

34 / 40

A deficiency in which complement component can lead to recurrent Neisseria infections?

C1 esterase

C5-C9

35 / 40

What is the treatment of choice for Bruton's Agammaglobulinemia?

Antifungal medication

Corticosteroids

Immunoglobulin replacement therapy

36 / 40

Ataxia-telangiectasia is associated with which kind of defect?

Enzyme production

Protein folding

DNA repair

37 / 40

What is the main characteristic of X-linked agammaglobulinemia?

Deficiency of T cells

Overproduction of B cells

Lack of B cells

38 / 40

Selective IgA deficiency often results in?

Muscle weakness

Blood clotting disorders

Mucosal infections

39 / 40

The absence of mature B cells is indicative of which condition?

Hyper IgM Syndrome

Chronic Granulomatous Disease

X-linked agammaglobulinemia

40 / 40

In X-linked agammaglobulinemia, the BTK gene mutation affects the development of?

T cells

Natural killer cells

B cells

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adminApril 3, 2024Last Updated: October 15, 2024

0 48 2 minutes read