Immunodeficiency Disorders MCQs with Answers

adminApril 3, 2024Last Updated: October 15, 2024

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Welcome to the Immunodeficiency Disorders MCQs with Answers. In this post, we have shared Immunodeficiency Disorders Online Test for different competitive exams. Find practice Immunodeficiency Disorders Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Immunodeficiency Disorders.

These are conditions characterized by inappropriate responses of the body’s immune system to infections and diseases. They are broadly classified according to causation into primary or genetic and secondary or acquired. Most of them are genetic; hence they refer to mutations in genes that affect the functions of cells of the immune system and thus predispose patients to infections. Examples of primary immunodeficiencies include SCID and CVID.

Secondary immunodeficiencies, acquired and due to etiologic factors exogenous to the patient himself, such as infections, malnutrition or immunosuppressive drugs. Probably the most known and frequent secondary immunodeficiency disease is HIV infection that leads to Acquired Immunodeficiency Syndrome (AIDS).

The diagnosis is accompanied by clinical evaluation, immunological testing, and genetic analysis. The patients need early diagnosis coupled with intervention to avoid severe complications in the conditions. Treatment could therefore be administered mainly through immunoglobulin replacement therapy, antibiotics to prevent infections, and sometimes through a stem cell or bone marrow transplant.

The scientific and clinical research of immunodeficiency diseases, such as HIV/AIDS, focuses on understanding the disease mechanism due to genetic or environmental factors that cause immunodeficiency disorders. There have been various advancements in different fields: diagnostic techniques, specific therapies, and the fate of the patient.

Immunodeficiency Disorders Online Quiz

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Test Name: Immunodeficiency Disorders MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Immunodeficiency Disorders

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1 / 40

Ataxia-telangiectasia is associated with increased risk of which disease?

Osteoporosis

Cardiovascular disease

Cancer

2 / 40

Which disorder is characterized by an inability to clear certain fungal and bacterial infections?

Chronic Granulomatous Disease

DiGeorge Syndrome

Common Variable Immunodeficiency

3 / 40

What is the genetic inheritance pattern of Wiskott-Aldrich Syndrome?

Autosomal dominant

Autosomal recessive

X-linked recessive

4 / 40

Hyper IgM Syndrome involves a defect in which gene?

TCR gene

CD40 ligand

IL-2 receptor

5 / 40

Common Variable Immunodeficiency (CVID) usually presents with?

Autoimmune disorders

Allergic reactions

Recurrent infections

6 / 40

Which disorder is characterized by the inability to produce antibodies?

Neutropenia

Lymphopenia

Agammaglobulinemia

7 / 40

Defects in the IL-2 receptor gamma chain can result in which immunodeficiency?

Chronic Granulomatous Disease

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

8 / 40

The primary cause of death in patients with Severe Combined Immunodeficiency (SCID) is?

Autoimmune diseases

Cancer

Infections

9 / 40

Which enzyme deficiency leads to Severe Combined Immunodeficiency (SCID)?

Phosphofructokinase

Alpha-1 antitrypsin

Adenosine deaminase

10 / 40

Hyper IgM syndrome is characterized by high levels of which immunoglobulin?

IgG

IgA

IgM

11 / 40

A deficiency in which complement component can lead to recurrent Neisseria infections?

C1 esterase

C5-C9

12 / 40

What is the most common primary immunodeficiency?

DiGeorge Syndrome

Selective IgA deficiency

Common Variable Immunodeficiency

13 / 40

The diagnostic hallmark of Chronic Granulomatous Disease is?

Low immunoglobulin levels

Lack of thymus

Defective neutrophil function

14 / 40

DiGeorge Syndrome is primarily caused by?

A deletion on chromosome 22

An HIV infection

A mutation in the B cell receptor

15 / 40

Hyper IgM Syndrome can result from mutations in which of the following?

IgA receptor

CD40 ligand

Complement factor

16 / 40

The absence of the thymus is a hallmark of which syndrome?

Bruton’s Agammaglobulinemia

DiGeorge Syndrome

Common Variable Immunodeficiency

17 / 40

The absence of mature B cells is indicative of which condition?

X-linked agammaglobulinemia

Hyper IgM Syndrome

Chronic Granulomatous Disease

18 / 40

Which primary immunodeficiency is often treated with bone marrow transplantation?

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

Hyper IgM Syndrome

19 / 40

Which primary immunodeficiency disorder involves a defect in the CD40 ligand gene?

Common Variable Immunodeficiency

Selective IgA Deficiency

Hyper IgM Syndrome

20 / 40

What is the main characteristic of X-linked agammaglobulinemia?

Deficiency of T cells

Lack of B cells

Overproduction of B cells

21 / 40

Selective IgA deficiency mainly affects which immunoglobulin?

IgA

IgG

IgM

22 / 40

Which primary immunodeficiency involves a defect in neutrophil chemotaxis?

Common Variable Immunodeficiency

Leukocyte Adhesion Deficiency

Bruton’s Agammaglobulinemia

23 / 40

What is a common treatment for many primary immunodeficiency disorders?

Antiviral drugs

Immunoglobulin replacement therapy

Antibiotics

24 / 40

Selective IgA deficiency often results in?

Blood clotting disorders

Mucosal infections

Muscle weakness

25 / 40

Chronic Granulomatous Disease is diagnosed using which test?

Flow cytometry

ELISA

Nitroblue tetrazolium test

26 / 40

Job's Syndrome is also known as?

Hyper IgM Syndrome

Hypogammaglobulinemia

Hyper IgE Syndrome

27 / 40

Which syndrome is associated with defective T-cell development and low calcium levels?

DiGeorge Syndrome

Severe Combined Immunodeficiency (SCID)

Hyper IgM Syndrome

28 / 40

Wiskott-Aldrich Syndrome affects which type of cells primarily?

Endothelial cells

Platelets and immune cells

Red blood cells

29 / 40

Severe Combined Immunodeficiency (SCID) affects which cells?

Both B and T cells

Only T cells

Only B cells

30 / 40

What is the treatment of choice for Bruton's Agammaglobulinemia?

Antifungal medication

Corticosteroids

Immunoglobulin replacement therapy

31 / 40

Wiskott-Aldrich Syndrome is caused by mutations in which gene?

WAS gene

IL-2 receptor gene

BTK gene

32 / 40

Chronic mucocutaneous candidiasis is primarily due to a defect in which type of cell?

B cells

Phagocytes

T cells

33 / 40

The "Boy in the Bubble" disease refers to?

X-linked agammaglobulinemia

Common Variable Immunodeficiency

Severe Combined Immunodeficiency (SCID)

34 / 40

A patient with recurrent bacterial infections and low levels of all immunoglobulins might have?

Common Variable Immunodeficiency

Selective IgA Deficiency

Chronic Granulomatous Disease

35 / 40

Which immunodeficiency is associated with defects in the phagocyte oxidase enzyme?

Chronic Granulomatous Disease

DiGeorge Syndrome

Wiskott-Aldrich Syndrome

36 / 40

Which of the following is a primary immunodeficiency disorder?

Severe Combined Immunodeficiency (SCID)

Tuberculosis

HIV/AIDS

37 / 40

In X-linked agammaglobulinemia, the BTK gene mutation affects the development of?

B cells

Natural killer cells

T cells

38 / 40

Which primary immunodeficiency can present with eczema, thrombocytopenia, and recurrent infections?

Wiskott-Aldrich Syndrome

Hyper IgM Syndrome

DiGeorge Syndrome

39 / 40

Ataxia-telangiectasia is associated with which kind of defect?

DNA repair

Enzyme production

Protein folding

40 / 40

Wiskott-Aldrich Syndrome includes symptoms like?

Only eczema

Only recurrent infections

Thrombocytopenia, eczema, recurrent infections

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adminApril 3, 2024Last Updated: October 15, 2024

0 47 2 minutes read